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Levocetirizine (as levocetirizine dihydrochloride) is a third-generation, non-sedating antihistamine, developed from the second-generation antihistamine cetirizine. Chemically, levocetirizine is simply the isolated levorotary enantiomer of cetirizine, which is sold as a racemic mixture.


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Medical uses

Levocetirizine is used for allergy symptoms including watery eyes, runny nose, sneezing, hives, and itching. The manufacturers claim it to be more effective with fewer side effects than previous second-generation drugs; however, there have been no published studies supporting this assertion. A study part-funded by the manufacturer UCB concluded it may be more effective than some other second- and third-generation anti-histamines, but did not compare it to cetirizine.


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Side effects

Levocetirizine is called a non-sedating antihistamine as it does not enter the brain in significant amounts, and is therefore unlikely to cause drowsiness. However, some people may experience some slight sleepiness, headache, mouth dryness, lightheadedness, vision problems (mainly blurred vision), palpitations and fatigue.


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Pharmacology

Levocetirizine is an antihistamine. It acts as an inverse agonist that decreases activity at histamine H1 receptors. This in turn prevents the release of other allergy chemicals and increase the blood supply to the area, and provides relief from the typical symptoms of hay fever. It does not prevent the actual release of histamine from mast cells.


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Chemistry

Chemically, levocetirizine is the active levorotary enantiomer of cetirizine, also called the l-enantiomer of cetirizine. It is a member of the diphenylmethylpiperazine group of antihistamines.


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History

Levocetirizine was first launched in 2001 by Belgian pharmaceutical company UCB.


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Availability

On 31 January 2017, the Food and Drug Administration approved Xyzal as an over-the-counter drug. Although the drug was only authorized by the FDA on 25 May 2007, it was already available in most European countries. Like many new drugs it entered the market at a higher price than currently available third and second generation antihistamines. In India, one form of the drug is available as Crohist MK tablets and syrup, a formulation of levocetirizine hydrochloride and montelukast. In India, Crohist MK is a Schedule 'H' drug and may only be prescribed by a registered medical practitioner. In Finland, Hungary, China, The United States and Kuwait the drug is sold over-the-counter.

Brand names

Levocetirizine is sold under the following brand names:

  • Xyzal in Australia, Austria, Croatia, Czech Republic, Finland, France, India, Ireland (also Rinozal), Italy, Lithuania, Netherlands, Poland, Portugal, Romania, Taiwan, Thailand, Turkey, The Philippines, Serbia, Slovakia, Slovenia, South Africa and UK. On May 25, 2007, the United States Food and Drug Administration approved Xyzal, where it is co-marketed by Sanofi-Aventis.
  • Xusal in Germany;
  • Xozal in Greece;
  • Xazal in Spain;
  • Xuzal in Mexico;
  • In Hungary it is marketed as Zilola (made by Richter Gedeon) and Histisynt (Actavis).
  • In India, levocetirizine is marketed by GlaxoSmithKline under the brand name Vozet. Torrent Pharma launched UVNIL for the rural market. Kaptab Pharmaceuticals markets mouth dissolving form in India.
  • In Pakistan levocetirizine was first launched in a liquid formulation by Novartis Consumer Health Division under the name of T-Day Syrup.
  • In Nepal levocetirizine is available in tablet with brand name Curin manufactured by Beximco Pharma.
  • In Chile, it is marketed as Zival and made by Laboratorio Saval.
  • In Sweden, which has a socialized health care system, the Swedish government will not pay for Xyzal, and it has been withdrawn from the market.

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References


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External links

  • Full US prescribing information Xyzal® (levocetirizine dihydrochloride) tablets and oral solution (provided by UCB, December 2010, pdf file)


Source of the article : Wikipedia

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